Harlequins’ players that featured for England at the Women’s Rugby World Cup return as captain Rachael Burford starts at fly-half while Vickii Cornborough and Abbie Scott start in the tight five.
Shaunagh Brown moves from second row to blindside flanker, while Jessica Wooden comes in to start at fullback.
For those that can’t make it to Loughborough, the match will be live streamed on England Rugby’s Facebook page, englandrugby.com and on premier15s.com
Ahead of the match, Co-Head Coach Gary Street said: “This should be a really exciting weekend for the new Tyrrells Premier15s as it sees the start of the return of players who have been away at the World Cup.
“We have had a great start to the season and the addition of Rachael Burford, Vickii Cornborough and Abbie Scott adds another layer to our exciting squad.
“Loughborough have recruited really well and we are looking forward to a stern test and hopefully another exciting match as it is the first to be streamed live this season.”